Highly enantioselective Michael addition of α,α-disubstituted aldehydes to nitroolefins

被引：0
|
作者：
Xing-Tao Guo
Feng Sha
Xin-Yan Wu
机构：
[1] East China University of Science and Technology,Key Laboratory for Advanced Materials and Institute of Fine Chemicals
来源：
Research on Chemical Intermediates | 2016年 / 42卷
关键词：
Chiral primary amine-thiourea; -Disubstituted aldehydes; Enantioselective organocatalysis; Michael addition; Nitroolefins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A highly enantioselective Michael addition reaction of α,α-disubstituted aldehydes to β-nitrostyrenes has been developed. In the presence of rosin-based chiral primary amine-thiourea, γ-nitroaldehydes were afforded in excellent enantioselectivities (up to 99 % ee) with up to 99 % yield.
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页码：6373 / 6380
页数：7
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