Pyrrolidine-oxyimide catalyzed asymmetric Michael addition of α,α-disubstituted aldehydes to nitroolefins

被引：11

作者：

Kumar, Togapur Pavan ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2015年 / 26卷 / 17期

关键词：

ALDOL REACTIONS; CONJUGATE ADDITION; QUATERNARY STEREOCENTERS; BETA-NITROALKENES; ENANTIOSELECTIVE CONSTRUCTION; TRIAZOLE-PYRROLIDINE; CHIRAL CATALYSTS; VINYL SULFONES; NITRO OLEFINS; KETONES;

D O I：

10.1016/j.tetasy.2015.07.009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organocatalytic enantioselective Michael addition of alpha,alpha-disubstituted aldehydes onto nitroolefins using pyrrolidine-oxyimide catalyst was reported. The reaction works effectively under neat conditions with 15 mol % of catalyst and 10 mol % of p-nitrobenzoic acid as an additive at 0 degrees C; this results in the formation of Michael adducts possessing an all-carbon quaternary center with good yields and enantioselectivities. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：907 / 911

页数：5

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