Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by a pyrrolidine-pyrazole

被引：10
|
作者：
Kumar, Togapur Pavan [1 ]
机构：
[1] CSIR, Div Nat Prod Chem, Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 18-19期
关键词：
ENANTIOSELECTIVE CONJUGATE ADDITION; C BOND FORMATION; ALDOL REACTIONS; BIFUNCTIONAL ORGANOCATALYSTS; NITRO-OLEFINS; EFFICIENT ORGANOCATALYSTS; BETA-NITROSTYRENES; VINYL SULFONES; ACID CATALYSIS; IONIC LIQUIDS;
D O I：
10.1016/j.tetasy.2014.07.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An effective protocol for the stereoselective Michael addition of aldehydes to nitroolefins using pyrrolidine-pyrazole as an organocatalyst is described. The catalytic cycle was found to be productive in terms of yield and selectivity, when performed under solvent-free reaction conditions and employing 15 mol % of catalyst and 10 mol % of benzoic acid at room temperature. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1286 / 1291
页数：6
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