Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases

被引：55

作者：

Scotece, Morena ^{[1
]}

Conde, Javier ^{[1
]}

Gomez, Rodolfo ^{[2
]}

Lopez, Veronica ^{[1
]}

Lago, Francisca ^{[3
]}

Jesus Gomez-Reino, Juan ^{[1
]}

Gualillo, Oreste ^{[1
]}

机构：

[1] Santiago Univ Clin Hosp, Inst Med Res IDIS, SERGAS,Res Lab 9, Lab Neuroendocrine Interact Rheumatol & Inflammat, Santiago De Compostela 15706, Spain

[2] Fdn Jimenez Diaz, Div Reumatol, E-28040 Madrid, Spain

[3] Santiago Univ Clin Hosp, Inst Med Res IDIS, SERGAS, Mol & Cellular Cardiol Lab,Res Lab 7, Santiago De Compostela 15706, Spain

来源：

THESCIENTIFICWORLDJOURNAL | 2011年 / 11卷

关键词：

white adipose tissue (WAT); adipokines; cytokines; rheumatic diseases; immune response; immune tolerance; metabolism; energetic homeostasis; GELATINASE-ASSOCIATED LIPOCALIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SYNTHASE TYPE-II; HUMAN ARTICULAR CHONDROCYTES; VISCERAL ADIPOSE-TISSUE; ACUTE-PHASE REACTANTS; KNEE OSTEOARTHRITIS; METABOLIC SYNDROME; SYNOVIAL-FLUID; TNF-ALPHA;

D O I：

10.1100/2011/290142

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert potent modulatory actions on target tissues involved in rheumatic diseases including cartilage, synovial, bone and immune cells. The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE).

引用

页码：1932 / 1947

页数：16

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