Gold-Catalyzed Cycloisomerization Reactions of 2-Tosylaminophenylprop-1-yn-3-ols as a Versatile Approach for Indole Synthesis

被引：115
|
作者：
Kothandaraman, Prasath [1 ]
Rao, Weidong [1 ]
Foo, Shi Jia [1 ]
Chan, Philip Wai Hong [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 27期
关键词：
gold; homogeneous catalysis; indoles; tandem reactions; unsaturated alcohols; ALLYLIC ALCOHOLS; DIRECT AMINATION; C-C; ALKYNES; PALLADIUM; DERIVATIVES; PLATINUM; BONDS; CYCLOPROPANATION; HYDROAMINATION;
D O I：
10.1002/anie.201000341
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical equation presented) A great combination: A putative indolyl-substituted vinyl gold species generated in situ from AuCl/AgOTf catalyzed the title transformation. Under these reaction conditions, indenyl-fused and 2,3-disubstituted indole derivatives were produced in good to excellent yields of up to 94% (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4619 / 4623
页数：5
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