Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

被引：1
|
作者：
Marusiak, A. A. [1 ]
Edwards, Z. C. [1 ]
Hugo, W. [2 ]
Trotter, E. W. [1 ]
Girotti, M. R. [3 ]
Stephenson, N. L. [1 ]
Kong, X. [2 ]
Gartside, M. G. [4 ]
Fawdar, S. [1 ]
Hudson, A. [1 ]
Breitwieser, W. [3 ]
Hayward, N. K. [4 ]
Marais, R. [3 ]
Lo, R. S. [2 ]
Brognard, J. [1 ]
机构：
[1] Canc Res UK Manchester Inst, Signalling Networks Canc, Manchester, Lancs, England
[2] Jonsson Comprehens Canc Ctr, Div Dermatol, Los Angeles, CA 90034 USA
[3] Canc Res UK Manchester Inst, Manchester, Lancs, England
[4] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷
关键词：
D O I：
10.1016/S0959-8049(14)70202-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
76
引用
收藏
页码：29 / 30
页数：2
相关论文
共 50 条
  • [41] The Hippo effector YAP promotes resistance to RAF and MEK targeted therapies
    Lin, Luping
    Sabnis, Amit
    Chan, Elton
    Olivas, Victor
    Cade, Lindsay
    Pazarentzos, Evangelos
    Asthana, Saurabh
    Neel, Dana
    Yan, Jenny Jiacheng
    Lu, Xinyuan
    Pham, Luu
    Wang, Mingxue
    Karachaliou, Niki
    Cao, Maria G.
    Manzano, Jose L.
    Ramirez, Jose L.
    Torres, Jose M.
    Buttitta, Fiamma
    Rudin, Charles M.
    Collisson, Eric A.
    Algazi, Alain
    Robinson, Eric
    Osman, Iman
    Munoz-Couselo, Eva
    Cortes, Javier
    Frederick, Dennie T.
    Cooper, Zachary A.
    McMahon, Martin
    Marchetti, Antonio
    Rosell, Rafael
    Flaherty, Keith T.
    Wargo, Jennifer A.
    Bivona, Trever G.
    CANCER RESEARCH, 2015, 75
  • [42] Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition
    Desaunay, Mathieu
    Poulikakos, Poulikos I.
    CANCER CELL, 2025, 43 (03) : 330 - 332
  • [43] Efficiency of B-RAF-/MEK-inhibitors in B-RAF mutated Ameloblastoma: Case report and review of literature
    Buettner, Reinhard
    Gueltekin, Sibel Elif
    Heydt, Carina
    Nogova, Lucia
    Meemboor, Sonja
    Kreppel, Matthias
    Aziz-Heiloun, Reem
    HELIYON, 2023, 9 (12)
  • [44] Drug resistance in targeted cancer therapies with RAF inhibitors
    Degirmenci, Ufuk
    Yap, Jiajun
    Sim, Yuen Rong M.
    Qin, Shiru
    Hu, Jiancheng
    CANCER DRUG RESISTANCE, 2021, 4 (03) : 665 - 683
  • [45] A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression
    Imoto, Hiroaki
    Rauch, Nora
    Neve, Ashish J.
    Khorsand, Fahimeh
    Kreileder, Martina
    Alexopoulos, Leonidas G.
    Rauch, Jens
    Okada, Mariko
    Kholodenko, Boris N.
    Rukhlenko, Oleksii S.
    BIOMOLECULES, 2023, 13 (08)
  • [46] RAF-like protein kinases mediate a deeply conserved, rapid auxin response
    Kuhn, Andre
    Roosjen, Mark
    Mutte, Sumanth
    Dubey, Shiv Mani
    Carrasco, Vanessa Polet Carrillo
    Boeren, Sjef
    Monzer, Aline
    Koehorst, Jasper
    Kohchi, Takayuki
    Nishihama, Ryuichi
    Fendrych, Matyas
    Sprakel, Joris
    Friml, Jiri
    Weijers, Dolf
    CELL, 2024, 187 (01) : 130 - 148.e17
  • [47] Inactivation of Receptor Tyrosine Kinases Overcomes Resistance to Targeted B-RAF Inhibitors in Melanoma Cell Lines
    O. O. Ryabaya
    A. A. Malysheva
    Yu. A. Khochenkova
    E. Sh. Solomko
    D. A. Khochenkov
    Molecular Biology, 2018, 52 : 398 - 405
  • [48] Inactivation of Receptor Tyrosine Kinases Overcomes Resistance to Targeted B-RAF Inhibitors in Melanoma Cell Lines
    Ryabaya, O. O.
    Malysheva, A. A.
    Khochenkova, Yu. A.
    Solomko, E. Sh.
    Khochenkov, D. A.
    MOLECULAR BIOLOGY, 2018, 52 (03) : 398 - 405
  • [49] BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
    Vido, Michael J.
    Le, Kaitlyn
    Hartsough, Edward J.
    Aplin, Andrew E.
    CELL REPORTS, 2018, 25 (06): : 1501 - +
  • [50] Dual RAF/MEK inhibitor VS-6766 enhances antitumor efficacy of KRAS G12C inhibitors through vertical inhibition of RAS, RAF and MEK
    Coma, Silvia
    Chowdhury, Sanjib
    Dilly, Julien
    Musteanu, Monica
    Barbacid, Mariano
    Aguirre, Andrew J.
    Pachter, Jonathan A.
    CANCER RESEARCH, 2022, 82 (12)
12345