DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

被引：83
|
作者：
Weterings, Eric [1 ]
Chen, David J. [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Radiat Oncol, Div Mol Radiat Biol, Dallas, TX 75390 USA
来源：
JOURNAL OF CELL BIOLOGY | 2007年 / 179卷 / 02期
关键词：
D O I：
10.1083/jcb.200705106
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA- dependent protein kinase ( DNA- PK) is one of the central enzymes involved in DNA double- strand break ( DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest. ndings on DNA- PK phosphorylation and offer a working model for the regulation of DNA- PK during DSB repair.
引用
收藏
页码：183 / 186
页数：4
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