DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

被引：83

作者：

Weterings, Eric ^{[1
]}

Chen, David J. ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Radiat Oncol, Div Mol Radiat Biol, Dallas, TX 75390 USA

来源：

JOURNAL OF CELL BIOLOGY | 2007年 / 179卷 / 02期

关键词：

D O I：

10.1083/jcb.200705106

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The DNA- dependent protein kinase ( DNA- PK) is one of the central enzymes involved in DNA double- strand break ( DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest. ndings on DNA- PK phosphorylation and offer a working model for the regulation of DNA- PK during DSB repair.

引用

页码：183 / 186

页数：4

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