DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

被引：83
|
作者：
Weterings, Eric [1 ]
Chen, David J. [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Radiat Oncol, Div Mol Radiat Biol, Dallas, TX 75390 USA
来源：
JOURNAL OF CELL BIOLOGY | 2007年 / 179卷 / 02期
关键词：
D O I：
10.1083/jcb.200705106
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA- dependent protein kinase ( DNA- PK) is one of the central enzymes involved in DNA double- strand break ( DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest. ndings on DNA- PK phosphorylation and offer a working model for the regulation of DNA- PK during DSB repair.
引用
收藏
页码：183 / 186
页数：4
相关论文
共 50 条
  • [1] DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    Dibiase, SJ
    Zeng, ZC
    Chen, R
    Hyslop, T
    Curran, WJ
    Iliakis, G
    CANCER RESEARCH, 2000, 60 (05) : 1245 - 1253
  • [2] Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation
    Udayakumar, D
    Bladen, CL
    Hudson, FZ
    Dynan, WS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) : 41631 - 41635
  • [3] Artemis and Nonhomologous End Joining-Independent Influence of DNA-Dependent Protein Kinase Catalytic Subunit on Chromosome Stability
    Stracker, Travis H.
    Williams, Bret R.
    Deriano, Ludovic
    Theunissen, Jan W.
    Adelman, Carrie A.
    Roth, David B.
    Petrini, John H. J.
    MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (02) : 503 - 514
  • [4] Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase
    Cheung, Joyce C. Y.
    Salerno, Brenda
    Hanakahi, Les A.
    NUCLEIC ACIDS RESEARCH, 2008, 36 (17) : 5713 - 5726
  • [5] Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    Ma, YM
    Pannicke, U
    Schwarz, K
    Lieber, MR
    CELL, 2002, 108 (06) : 781 - 794
  • [6] The DNA-dependent protein kinase: the director at the end
    Meek, K
    Gupta, S
    Ramsden, DA
    Lees-Miller, SP
    IMMUNOLOGICAL REVIEWS, 2004, 200 : 132 - 141
  • [7] Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase
    Takahagi, Masahiko
    Tatsumi, Kouichi
    FEBS JOURNAL, 2006, 273 (13) : 3063 - 3075
  • [8] DNA end sequestration by DNA-dependent protein kinase and end joining of sterically constrained substrates in whole-cell extracts
    Lee, JW
    Inamdar, KV
    Hannah, MF
    Lees-Miller, SP
    Povirk, LF
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2003, 42 (04) : 279 - 287
  • [9] DNA-dependent protein kinase
    Jackson, SP
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (07): : 935 - 938
  • [10] The DNA-dependent protein kinase
    Smith, GCM
    Jackson, SP
    GENES & DEVELOPMENT, 1999, 13 (08) : 916 - 934
12345