Computational cancer biology: education is a natural key to many locks

被引:5
|
作者
Emmert-Streib, Frank [1 ]
Zhang, Shu-Dong [2 ]
Hamilton, Peter [2 ]
机构
[1] Queens Univ Belfast, Fac Med Hlth & Life Sci, Sch Med Dent & Biomed Sci, Ctr Canc Res & Cell Biol,Computat Biol & Machine, Belfast, Antrim, North Ireland
[2] Queens Univ Belfast, Fac Med Hlth & Life Sci, Sch Med Dent & Biomed Sci, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland
关键词
Cancer; Computational biology; Genomics data; Computational oncology; Computational genomics; Statistical genomics; Systems medicine; EXPRESSION; CLASSIFICATION; CARCINOMAS;
D O I
10.1186/s12885-014-1002-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Oncology is a field that profits tremendously from the genomic data generated by high-throughput technologies, including next-generation sequencing. However, in order to exploit, integrate, visualize and interpret such high-dimensional data efficiently, non-trivial computational and statistical analysis methods are required that need to be developed in a problem-directed manner. Discussion: For this reason, computational cancer biology aims to fill this gap. Unfortunately, computational cancer biology is not yet fully recognized as a coequal field in oncology, leading to a delay in its maturation and, as an immediate consequence, an under-exploration of high-throughput data for translational research. Summary: Here we argue that this imbalance, favoring 'wet lab-based activities', will be naturally rectified over time, if the next generation of scientists receives an academic education that provides a fair and competent introduction to computational biology and its manifold capabilities. Furthermore, we discuss a number of local educational provisions that can be implemented on university level to help in facilitating the process of harmonization.
引用
收藏
页数:6
相关论文
共 50 条
  • [31] The NAD metabolome — a key determinant of cancer cell biology
    Alberto Chiarugi
    Christian Dölle
    Roberta Felici
    Mathias Ziegler
    Nature Reviews Cancer, 2012, 12 : 741 - 752
  • [32] CK2: A key player in cancer biology
    Trembley, J. H.
    Wang, G.
    Unger, G.
    Slaton, J.
    Ahmed, K.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (11-12) : 1858 - 1867
  • [33] The NAD metabolome - a key determinant of cancer cell biology
    Chiarugi, Alberto
    Dolle, Christian
    Felici, Roberta
    Ziegler, Mathias
    NATURE REVIEWS CANCER, 2012, 12 (11) : 741 - 752
  • [34] Glycosaminoglycans: key players in cancer cell biology and treatment
    Afratis, Nikos
    Gialeli, Chrisostomi
    Nikitovic, Dragana
    Tsegenidis, Theodore
    Karousou, Evgenia
    Theocharis, Achilleas D.
    Pavao, Mauro S.
    Tzanakakis, George N.
    Karamanos, Nikos K.
    FEBS JOURNAL, 2012, 279 (07) : 1177 - 1197
  • [35] Natural killer cells in cancer biology and therapy
    Song-Yang Wu
    Tong Fu
    Yi-Zhou Jiang
    Zhi-Ming Shao
    Molecular Cancer, 19
  • [36] Biology of natural killer cells in cancer and infection
    Miller, JS
    CANCER INVESTIGATION, 2002, 20 (03) : 405 - 419
  • [37] Natural killer cells in cancer biology and therapy
    Wu, Song-Yang
    Fu, Tong
    Jiang, Yi-Zhou
    Shao, Zhi-Ming
    MOLECULAR CANCER, 2020, 19 (01)
  • [38] The Many Faces of Gene Regulation in Cancer: A Computational Oncogenomics Outlook
    Hernandez-Lemus, Enrique
    Reyes-Gopar, Helena
    Espinal-Enriquez, Jesus
    Ochoa, Soledad
    GENES, 2019, 10 (11)
  • [39] Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms Using Computational Systems Biology Approaches
    Aghakhani, Sahar
    Zerrouk, Naouel
    Niarakis, Anna
    CANCERS, 2021, 13 (01) : 1 - 26
  • [40] Not the same key for all the locks Re: Reasons for delayed presentation in oral and oropharyngeal cancer: the patients' perspective
    Kanatas, Anastasios
    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2012, 50 (03): : E48 - E48