The talin wags the dog: new insights into integrin activation

被引：30
|
作者：
Cram, EJ [1 ]
Schwarzbauer, JE [1 ]
机构：
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源：
TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 02期
关键词：
D O I：
10.1016/j.tcb.2003.12.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.
引用
收藏
页码：55 / 57
页数：3
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