The talin wags the dog: new insights into integrin activation

被引：30

作者：

Cram, EJ ^{[1
]}

Schwarzbauer, JE ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.tcb.2003.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.

引用

页码：55 / 57

页数：3

共 50 条

[31] Talin and kindlin: the one-two punch in integrin activation
Feng Ye
Adam K.Snider
Mark H.Ginsberg
Frontiers of Medicine, 2014, 8 (01) : 6 - 16
[32] The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
Calderwood, DA
Zent, R
Grant, R
Rees, DJG
Hynes, RO
Ginsberg, MH
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) : 28071 - 28074
[33] An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton
Tanentzapf, Guy
Brown, Nicholas H.
NATURE CELL BIOLOGY, 2006, 8 (06) : 601 - 606
[34] Kindlin Cooperates with Talin for Integrin Activation, a Molecular Dynamics Approach
Haydari, Zainab
Shams, Hengameh
Jahed, Zeinab
Mofrad, Mohammad
BIOPHYSICAL JOURNAL, 2020, 118 (03) : 504A - 504A
[35] An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton
Guy Tanentzapf
Nicholas H. Brown
Nature Cell Biology, 2006, 8 : 601 - 606
[36] β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation
Anthis, Nicholas J.
Haling, Jacob R.
Oxley, Camilla L.
Memo, Massimiliano
Wegener, Kate L.
Lim, Chinten J.
Ginsberg, Mark H.
Campbell, Iain D.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (52) : 36700 - 36710
[37] Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth
Wang, Yifan
Zhang, Xiaolong
Tian, Jilai
Shan, Jinjun
Hu, Yunfeng
Zhai, Yiqian
Guo, Jun
FASEB JOURNAL, 2019, 33 (05): : 6311 - 6326
[38] When the tail wags the dog
Guillaume Aulanier
Nature Physics, 2016, 12 : 998 - 999
[39] When the tail wags the dog
Greco, Peter M.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2011, 140 (05) : 603 - 603
[40] Kindlin: helper, co-activator, or booster of talin in integrin activation?
Ye, Feng
Petrich, Brian G.
CURRENT OPINION IN HEMATOLOGY, 2011, 18 (05) : 356 - 360

← 1 2 3 4 5 →