Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

被引：245

作者：

Melzer, Sarah ^{[1
,2
]}

Michael, Magdalena ^{[1
,2
]}

Caputi, Antonio ^{[1
,2
]}

Eliava, Marina ^{[1
,2
]}

Fuchs, Elke C. ^{[1
,2
]}

Whittington, Miles A. ^{[3
]}

Monyer, Hannah ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Fac Med, Dept Clin Neurobiol, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, D-69120 Heidelberg, Germany

[3] Newcastle Univ, Sch Med, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

SCIENCE | 2012年 / 335卷 / 6075期

基金：

美国国家科学基金会; 欧洲研究理事会;

关键词：

SPATIAL REPRESENTATION; THETA OSCILLATIONS; MEDIAL SEPTUM; INTERNEURONS; RAT; EXPRESSION; DIVERSITY; CA1;

D O I：

10.1126/science.1217139

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range gamma-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.

引用

页码：1506 / 1510

页数：5

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