Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

被引：245
|
作者：
Melzer, Sarah [1 ,2 ]
Michael, Magdalena [1 ,2 ]
Caputi, Antonio [1 ,2 ]
Eliava, Marina [1 ,2 ]
Fuchs, Elke C. [1 ,2 ]
Whittington, Miles A. [3 ]
Monyer, Hannah [1 ,2 ]
机构：
[1] Heidelberg Univ, Fac Med, Dept Clin Neurobiol, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
[3] Newcastle Univ, Sch Med, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
SCIENCE | 2012年 / 335卷 / 6075期
基金：
美国国家科学基金会; 欧洲研究理事会;
关键词：
SPATIAL REPRESENTATION; THETA OSCILLATIONS; MEDIAL SEPTUM; INTERNEURONS; RAT; EXPRESSION; DIVERSITY; CA1;
D O I：
10.1126/science.1217139
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range gamma-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
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页码：1506 / 1510
页数：5
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