Rho GTPases: Masters of T lymphocyte migration and activation

被引：64

作者：

Rougerie, Pablo ^{[1
]}

Delon, Jerome ^{[1
]}

机构：

[1] Univ Paris 05, CNRS, INSERM, UMR 8104,Dept Immunol Hematol,U1016,Inst Cochin, F-75014 Paris, France

来源：

IMMUNOLOGY LETTERS | 2012年 / 142卷 / 1-2期

关键词：

Rho GTPases; Signalling; T cell; Activation; Migration; Adhesion; Morphological polarization; ACTIN STRESS FIBERS; BINDING PROTEIN RHO; IMMUNOLOGICAL SYNAPSE; CELL-ACTIVATION; TRANSENDOTHELIAL MIGRATION; DENDRITIC CELLS; INTEGRIN LFA-1; FAMILY GTPASES; CYTOSKELETAL REORGANIZATION; NEUTROPHIL CHEMOTAXIS;

D O I：

10.1016/j.imlet.2011.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rho GTPases are key signal transducer elements activated in T cells by both chemokine and antigen receptors. These two signalling pathways control the two main functions of T lymphocytes: motility and activation. Rho GTPases are thus crucial for the development of an adequate immune response. In this review, we mostly focus on the roles of RhoA, Rac1 and Cdc42 in T cells. We show their importance in phenomena such as adhesion, morphological polarization, migration and antigen recognition. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 13

页数：13

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