Rho GTPases: Masters of T lymphocyte migration and activation

被引：64
|
作者：
Rougerie, Pablo [1 ]
Delon, Jerome [1 ]
机构：
[1] Univ Paris 05, CNRS, INSERM, UMR 8104,Dept Immunol Hematol,U1016,Inst Cochin, F-75014 Paris, France
来源：
IMMUNOLOGY LETTERS | 2012年 / 142卷 / 1-2期
关键词：
Rho GTPases; Signalling; T cell; Activation; Migration; Adhesion; Morphological polarization; ACTIN STRESS FIBERS; BINDING PROTEIN RHO; IMMUNOLOGICAL SYNAPSE; CELL-ACTIVATION; TRANSENDOTHELIAL MIGRATION; DENDRITIC CELLS; INTEGRIN LFA-1; FAMILY GTPASES; CYTOSKELETAL REORGANIZATION; NEUTROPHIL CHEMOTAXIS;
D O I：
10.1016/j.imlet.2011.12.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rho GTPases are key signal transducer elements activated in T cells by both chemokine and antigen receptors. These two signalling pathways control the two main functions of T lymphocytes: motility and activation. Rho GTPases are thus crucial for the development of an adequate immune response. In this review, we mostly focus on the roles of RhoA, Rac1 and Cdc42 in T cells. We show their importance in phenomena such as adhesion, morphological polarization, migration and antigen recognition. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 13
页数：13
相关论文
共 50 条
  • [31] Rho GTPases and cell migration-fibroblast wound healing
    Nobes, CD
    REGULATORS AND EFFECTORS OF SMALL GTPASES, PT D: RHO FAMILY, 2000, 325 : 441 - 449
  • [32] Rho GTPases
    Mackay, DJG
    Hall, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (33) : 20685 - 20688
  • [33] Small GTPases in lymphocyte biology -: Rho proteins take center stage
    Henning, S
    Cleverley, S
    IMMUNOLOGIC RESEARCH, 1999, 20 (01) : 29 - 42
  • [34] RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
    Zhang, Shuangmin
    Zhou, Xuan
    Lang, Richard A.
    Guo, Fukun
    PLOS ONE, 2012, 7 (03):
  • [35] GTPases and T cell activation
    Cantrell, DA
    IMMUNOLOGICAL REVIEWS, 2003, 192 (01) : 122 - 130
  • [36] Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases
    Ray, Ramesh M.
    Bavaria, Mitulkumar N.
    Bhattacharya, Sujoy
    Johnson, Leonard R.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2011, 300 (06): : G988 - G997
  • [37] A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration (vol 6, 7721, 2015)
    Cao, Xuan
    Kaneko, Tomonori
    Li, Jenny S.
    Liu, An-Dong
    Voss, Courtney
    Li, Shawn S. C.
    NATURE COMMUNICATIONS, 2015, 6
  • [38] Lck regulates Vav activation of members of the Rho family of GTPases
    Han, JW
    Das, B
    Wei, W
    VanAelst, L
    Mosteller, RD
    Khosravifar, R
    Westwick, JK
    Der, CJ
    Broek, D
    MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) : 1346 - 1353
  • [39] An ELISA based assay to detect activation of Rho family GTPases
    Cheng, Li
    Davis, Ashley
    Middleton, Kim
    CANCER RESEARCH, 2006, 66 (08)
  • [40] Activation of STAT transcription factors by the Rho-family GTPases
    Corry, Jessica
    Mott, Helen R.
    Owen, Darerca
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2020, 48 (05) : 2213 - 2227
12345