Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety

被引：0
|
作者：
El-Kateb, Ahmed A. [1 ]
Abd El-Rahman, Naglaa M. [1 ,2 ]
Saleh, Tamer S. [1 ,3 ]
Zeid, Ibrahim F. [4 ]
Mady, Mohamed F. [1 ]
机构：
[1] Natl Res Ctr, Green Chem Dept, Cairo 12622, Egypt
[2] Jazan Univ, Fac Sci, Dept Chem, Jazan, Saudi Arabia
[3] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia
[4] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, El Menoufia, Egypt
来源：
LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION | 2012年 / 9卷 / 01期
关键词：
Green chemistry; Enaminone; Pyrazolo[1,5-a]pyrimidine; Aryl Sulfone; Microwave irradiation; ADENOSINE ANTAGONISTS; RHEUMATIC DISEASES; XANTHINE-OXIDASE; INHIBITORS; DERIVATIVES; PYRAZOLO<3,4-D>PYRIMIDINES; OSTEOARTHRITIS; ETORICOXIB; PAIN;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A facile, rapid and efficient microwave-assisted procedure for the synthesis of novel pyrazole, pyrimidine, and pyrazolo[1,5-a]pyrimidines linked to sulfonyl dibenzene moiety via the reaction of E-3-(N, N-dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one 3 with the appropriate amines described here. In general, microwave procedure as an eco-friendly energy source offers advantages such as a shorter reaction time, simple workup, reaction selectivity and improves an overall yield compared with conventional methods. The structures of all the compounds were confirmed by analytical and spectral data. [Ahmed A. El-Kateb, Naglaa M. Abd El-Rahman, Tamer S. Saleh, Ibrahim F. Zeid, Mohamed F. Mady. Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety. Life Science Journal 2012; 9(1):711-718]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 102
引用
收藏
页码：711 / 718
页数：8
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