Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety

被引：0

作者：

El-Kateb, Ahmed A. ^{[1
]}

Abd El-Rahman, Naglaa M. ^{[1
,2
]}

Saleh, Tamer S. ^{[1
,3
]}

Zeid, Ibrahim F. ^{[4
]}

Mady, Mohamed F. ^{[1
]}

机构：

[1] Natl Res Ctr, Green Chem Dept, Cairo 12622, Egypt

[2] Jazan Univ, Fac Sci, Dept Chem, Jazan, Saudi Arabia

[3] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia

[4] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, El Menoufia, Egypt

来源：

LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION | 2012年 / 9卷 / 01期

关键词：

Green chemistry; Enaminone; Pyrazolo[1,5-a]pyrimidine; Aryl Sulfone; Microwave irradiation; ADENOSINE ANTAGONISTS; RHEUMATIC DISEASES; XANTHINE-OXIDASE; INHIBITORS; DERIVATIVES; PYRAZOLO<3,4-D>PYRIMIDINES; OSTEOARTHRITIS; ETORICOXIB; PAIN;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A facile, rapid and efficient microwave-assisted procedure for the synthesis of novel pyrazole, pyrimidine, and pyrazolo[1,5-a]pyrimidines linked to sulfonyl dibenzene moiety via the reaction of E-3-(N, N-dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one 3 with the appropriate amines described here. In general, microwave procedure as an eco-friendly energy source offers advantages such as a shorter reaction time, simple workup, reaction selectivity and improves an overall yield compared with conventional methods. The structures of all the compounds were confirmed by analytical and spectral data. [Ahmed A. El-Kateb, Naglaa M. Abd El-Rahman, Tamer S. Saleh, Ibrahim F. Zeid, Mohamed F. Mady. Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety. Life Science Journal 2012; 9(1):711-718]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 102

引用

页码：711 / 718

页数：8

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