Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice

被引：74
|
作者：
Liu, JQ [1 ]
Na, SQ [1 ]
Glasebrook, A [1 ]
Fox, N [1 ]
Solenberg, PJ [1 ]
Zhang, Q [1 ]
Song, HY [1 ]
Yang, DD [1 ]
机构：
[1] Eli Lilly & Co, Dept Biores Technol & Prot, Indianapolis, IN 46285 USA
来源：
IMMUNITY | 2001年 / 15卷 / 01期
关键词：
D O I：
10.1016/S1074-7613(01)00162-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have found that DR6,a member of the TNF receptor family, is highly expressed in resting T cells and downregulated in activated T cells. DR6-targeted mutant mice were generated and showed normal development. However, DR6(-/-) CD4(+) T cells hyperproliferated in response to TCR-mediated stimulation and protein antigen challenge. Activated DR6(-/-) CD4(+) T cells exhibited upregulated CD25 expression and enhanced proliferation in response to exogenous IL-2 stimulation. In addition, increased CD28 and reduced CTLA-4 expression were observed in these cells. Enhanced Th2 cytokine production by activated DR6(/-) CD4(+) T cells was associated with the increased transcription factor NF-ATc in nuclei. DR6, therefore, functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses.
引用
收藏
页码：23 / 34
页数：12
相关论文
共 50 条
  • [31] Th2 Skewing by Activation of Nrf2 in CD4+ T Cells
    Rockwell, Cheryl E.
    Zhang, Mingcai
    Fields, Patrick E.
    Klaassen, Curtis D.
    JOURNAL OF IMMUNOLOGY, 2012, 188 (04): : 1630 - 1637
  • [32] Reprogrammed fibrocytes induce a mixed Th1/Th2 cytokine response of naïve CD4+ T cells
    Abelardo Medina
    Aziz Ghahary
    Molecular and Cellular Biochemistry, 2011, 346 : 89 - 94
  • [33] Shb deficient mice display an augmented TH2 response in peripheral CD4+T cells
    Gustafsson, Karin
    Calounova, Gabriela
    Hjelm, Fredrik
    Kriz, Vitezslav
    Heyman, Birgitta
    Gronvik, Kjell-Olov
    Mostoslavsky, Gustavo
    Welsh, Michael
    BMC IMMUNOLOGY, 2011, 12
  • [34] Cytokine production and CD4+ T-cell proliferation induced by myelin basic protein in health and multiple sclerosis
    不详
    IMMUNOBIOLOGY, 2005, 210 (6-8) : 607 - 607
  • [35] CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm
    Hirahara, Kiyoshi
    Nakayama, Toshinori
    INTERNATIONAL IMMUNOLOGY, 2016, 28 (04) : 163 - 171
  • [36] Regulation of Th2 cytokine production by CD4+CD25+ T cells depends on type and concentration of allergen
    Bellinghausen, I
    König, B
    Böttcher, I
    Knop, J
    Saloga, J
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (02)
  • [37] L-citrulline Metabolism in Mice augments cD4+ T cell Proliferation and cytokine Production In Vitro, and accumulation in the Mycobacteria-infected lung
    Lange, Shannon M.
    McKell, Melanie C.
    Schmidt, Stephanie M.
    Hossfeld, Austin P.
    Chaturvedi, Vandana
    Kinder, Jeremy M.
    McAlees, Jaclyn W.
    Lewkowich, Ian P.
    Way, Sing Sing
    Turner, Joanne
    Qualls, Joseph E.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [38] CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance
    Inobe, M
    Schwartz, RH
    JOURNAL OF IMMUNOLOGY, 2004, 173 (12): : 7239 - 7248
  • [39] Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells
    Mamchak, Alusha A.
    Sullivan, Brandon M.
    Hou, Baidong
    Lee, Linda M.
    Gilden, Julia K.
    Krummel, Matthew F.
    Locksley, Richard M.
    DeFranco, Anthony L.
    JOURNAL OF IMMUNOLOGY, 2008, 181 (08): : 5374 - 5385
  • [40] Abdominal visceral adiposity influences CD4+ T cell cytokine production in pregnancy
    Ozias, Marlies K.
    Li, Shengqi
    Hull, Holly R.
    Brooks, William M.
    Petroff, Margaret G.
    Carlson, Susan E.
    CYTOKINE, 2015, 71 (02) : 405 - 408
12345