Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice

被引：74

作者：

Liu, JQ ^{[1
]}

Na, SQ ^{[1
]}

Glasebrook, A ^{[1
]}

Fox, N ^{[1
]}

Solenberg, PJ ^{[1
]}

Zhang, Q ^{[1
]}

Song, HY ^{[1
]}

Yang, DD ^{[1
]}

机构：

[1] Eli Lilly & Co, Dept Biores Technol & Prot, Indianapolis, IN 46285 USA

来源：

IMMUNITY | 2001年 / 15卷 / 01期

关键词：

D O I：

10.1016/S1074-7613(01)00162-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have found that DR6,a member of the TNF receptor family, is highly expressed in resting T cells and downregulated in activated T cells. DR6-targeted mutant mice were generated and showed normal development. However, DR6(-/-) CD4(+) T cells hyperproliferated in response to TCR-mediated stimulation and protein antigen challenge. Activated DR6(-/-) CD4(+) T cells exhibited upregulated CD25 expression and enhanced proliferation in response to exogenous IL-2 stimulation. In addition, increased CD28 and reduced CTLA-4 expression were observed in these cells. Enhanced Th2 cytokine production by activated DR6(/-) CD4(+) T cells was associated with the increased transcription factor NF-ATc in nuclei. DR6, therefore, functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses.

引用

页码：23 / 34

页数：12

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