TNF-α but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis

被引：0
|
作者：
Mariani, E
Tarozzi, A
Meneghetti, A
Cattini, L
Facchini, A
机构：
[1] Ist Ric Codivilla Putti, IOR, Lab Immunol & Genet, I-40136 Bologna, Italy
[2] Univ Bologna, Dipartimento Med & Gastroenterol, Bologna, Italy
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 13卷 / 02期
关键词：
osteosarcoma cell lines; NK lysis; adhesion molecules; bone remodelling cytokines;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TNF-alpha-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-alpha, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-alpha treatment but not by IL-1 and IL-6 stimulation.
引用
收藏
页码：349 / 353
页数：5
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