Hepatic arterial floxuridine as second-line treatment for systemic fluorouracil-resistant colorectal liver metastases

被引:24
|
作者
Fordy, C [1 ]
Glover, C [1 ]
Davies, MM [1 ]
Allen-Mersh, TG [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Dept Gastrointestinal Surg, London, England
关键词
colorectal liver metastases; chemotherapy; fluorouracil resistance; hepatic arterial floxuridine;
D O I
10.1038/bjc.1998.627
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatic arterial floxuridine (HAI) in 35 patients with systemic fluorouracil/folinic acid-resistant colorectal liver metastases achieved a 14% partial response and 26% disease stabilization rate, with a median response duration of 7 months from onset of HAI.
引用
收藏
页码:1058 / 1060
页数:3
相关论文
共 50 条
  • [41] TREATMENT INTERRUPTIONS AND COMPLICATIONS WITH 2 CONTINUOUS HEPATIC-ARTERY FLOXURIDINE INFUSION SYSTEMS IN COLORECTAL LIVER METASTASES
    FORDY, C
    BURKE, D
    EARLAM, S
    TWORT, P
    ALLENMERSH, TG
    BRITISH JOURNAL OF CANCER, 1995, 72 (04) : 1023 - 1025
  • [42] Hepatic arterial oxaliplatin plus intravenous 5-fluorouracil and cetuximab for first-line treatment of colorectal liver metastases: A multicenter phase II trial
    Malka, David
    Verret, Benjamin
    Faron, Matthieu
    Guimbaud, Rosine
    Caramella, Caroline
    Edeline, Julien
    Galais, Marie-Pierre
    Bengrine-Lefevre, Leila
    Smith, Denis
    Dupont-Bierre, Eric
    De Baere, Thierry
    Goere, Diane
    Dartigues, Peggy
    Lacroix, Ludovic
    Gelli, Maximiliano
    Pignon, Jean-Pierre
    Ducreux, Michel
    EUROPEAN JOURNAL OF CANCER, 2023, 195
  • [43] CETUXIMAB WITH HEPATIC ARTERIAL INFUSION OF CHEMOTHERAPY FOR THE TREATMENT OF COLORECTAL CANCER LIVER METASTASES
    Neyns, B.
    Aerts, M.
    Van Nieuwenhove, Y.
    Fontaine, C.
    De Coster, L.
    Schallier, D.
    Vanderauwera, J.
    De Munck, F.
    Vandenbroucke, F.
    Everaert, H.
    Meert, V.
    De Mey, J.
    De Ridder, M.
    Delvaux, G.
    De Greve, J.
    ANTICANCER RESEARCH, 2008, 28 (5C) : 3185 - 3186
  • [44] Cetuximab with hepatic arterial infusion of chemotherapy for the treatment of colorectal cancer liver metastases
    Neyns, Bart
    Aerts, Maridi
    Van Nieuwenhove, Yves
    Fontaine, Christel
    De Coster, Lore
    Schallier, Dennis
    Vanderauwera, Jacques
    De Munck, Floris
    Vandenbroucke, Frederik
    Everaert, Hendrik
    Meert, Vanessa
    De Mey, Johan
    De Ridder, Mark
    Delvaux, Georges
    De Greve, Jacques
    ANTICANCER RESEARCH, 2008, 28 (4C) : 2459 - 2467
  • [45] Treatment of multiple colorectal liver metastases by hepatic arterial infusion of a suicide gene
    Pope, IM
    Yates, J
    Mellor, G
    ODowd, G
    Christmas, S
    Klatzmann, D
    Poston, GJ
    Kinsella, AR
    CANCER GENE THERAPY, 1997, 4 (01) : 70 - 71
  • [46] Place of hepatic intra-arterial chemotherapy in the treatment of colorectal liver metastases
    Allard, M. -A.
    Malka, D.
    JOURNAL OF VISCERAL SURGERY, 2014, 151 : S21 - S24
  • [47] Second-line systemic treatment for advanced cholangiocarcinoma
    Rogers, Jane Elizabeth
    Law, Lindsey
    Nguyen, D. Van
    Qiao, Wei
    Javle, Milind M.
    Kaseb, Ahmed Omar
    Shroff, Rachna T.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (03)
  • [48] Cholangiocarcinoma: the quest for a second-line systemic treatment
    Vienot, Angelique
    Neuzillet, Cindy
    TRANSLATIONAL CANCER RESEARCH, 2019, 8 : S275 - S288
  • [49] Second-line systemic treatment for advanced cholangiocarcinoma
    Rogers, Jane E.
    Law, Lindsey
    Nguyen, Van D.
    Qiao, Wei
    Javle, Milind M.
    Kaseb, Ahmed
    Shroff, Rachna T.
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2014, 5 (06) : 408 - 413
  • [50] TREATMENT OF LIVER METASTASES FROM COLORECTAL-CANCER WITH CONTINUOUS HIGH-DOSE INTRAARTERIAL FLOXURIDINE (FUDR) AND SYSTEMIC FLUOROURACIL - A PHASE-2 STUDY
    PLANTING, AST
    RUNHAAR, EA
    VERWEY, J
    TAAL, BG
    BLIJHAM, G
    NEYT, JP
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1989, 25 (12): : 1887 - 1888