Epigenetic changes in tumor microenvironment

被引：20
|
作者：
Dey, P. [1 ]
机构：
[1] Postgrad Inst Med Educ & Res, Dept Cytol, Chandigarh 160012, India
来源：
INDIAN JOURNAL OF CANCER | 2011年 / 48卷 / 04期
关键词：
Carcinogenesis; epigenetics; microenvironment; stroma; tumor; EPITHELIAL-MESENCHYMAL TRANSITIONS; GENETIC ALTERATIONS; DNA METHYLATION; PROSTATE-CANCER; BREAST-CANCER; MICRODISSECTED STROMA; PROMOTER METHYLATION; MAMMARY-CARCINOMA; CELLS; EXPRESSION;
D O I：
10.4103/0019-509X.92246
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The drama of cancer is not the solo performance of the malignant cells. Microenvironment of the tumor has significant contribution in carcinogenesis. Recent evidences show distinct gene promoter methylation in stromal cells of various malignant and pre-malignant tumors. These changes probably create unique tumor microenvironment, which is responsible for initiation, proliferation, invasion, and metastasis of tumor cells. In this mini review the role of epigenetic changes of tumor microenvironment in carcinogenesis has been discussed.
引用
收藏
页码：507 / 512
页数：6
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