Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities

被引：9

作者：

dos Santos, Erison Santana ^{[1
]}

Wagner, Vivian Petersen ^{[2
]}

Ramos, Joab Cabral ^{[1
]}

Lambert, Daniel W. ^{[2
]}

Castilho, Rogerio Moraes ^{[3
,4
]}

Leme, Adriana Franco Paes ^{[5
]}

机构：

[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, Brazil

[2] Univ Sheffield, Fac Med Dent & Hlth, Sheffield 152607, England

[3] Univ Michigan, Sch Dent, Div Oral Pathol Radiol & Med, Dept Periodont & Oral Med,Lab Epithelial Biol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[5] Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Campinas, Brazil

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 164卷

关键词：

HNSCC; Methylation; Histones; ncRNAs; Tumor microenvironment; SQUAMOUS-CELL CARCINOMA; SECRETORY PHENOTYPE; METASTATIC HEAD; DOWN-REGULATION; MESSENGER-RNA; T-CELLS; GROWTH; MACROPHAGES; EXPRESSION; PROMOTE;

D O I：

10.1016/j.critrevonc.2021.103397

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck cancer is globally challenging due to the resistance to therapy and aggressive behavior leading to high rates of mortality. Recent findings show that the tumor microenvironment plays a role in the maintenance and progression of many solid tumors, including head and neck cancer. The mechanisms involved in the modulation and regulation of the tumor microenvironment remain poorly understood. Increasing evidence suggests that epigenetic events can modulate the crosstalk between neoplastic and non-neoplastic cells during tumor progression. In this review, we explore the current understanding of the involvement of epigenetic events in the modulation of the tumor microenvironment and its impact on head and neck cancer behavior. We also explore the latest therapeutic strategies that use epigenetic-modulating drugs to manage tumor growth and progression.

引用

页数：8

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