DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia

被引：21
|
作者：
Dhingra, Sakshi [1 ]
Kaur, Kohinoor [1 ]
Taneja, Neetu K. [1 ]
Tyagi, Jaya S. [1 ]
机构：
[1] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India
来源：
FEMS MICROBIOLOGY LETTERS | 2012年 / 330卷 / 01期
关键词：
DevR; DosR; DevR binding peptide; phage display; CARBON-MONOXIDE; TRANSCRIPTION; ACTIVATION; OPERON; ASSAYS;
D O I：
10.1111/j.1574-6968.2012.02534.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M.tb). Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained. DevRS1 inhibited DevR-regulated transcription and survival of nonreplicating tubercle bacilli in a hypoxia model of dormancy. DevRS1 peptide-mediated inhibition demonstrates the efficacy of intercepting DevR function to block hypoxic adaptation of M.tb.
引用
收藏
页码：66 / 71
页数：6
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