DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia

被引：21

作者：

Dhingra, Sakshi ^{[1
]}

Kaur, Kohinoor ^{[1
]}

Taneja, Neetu K. ^{[1
]}

Tyagi, Jaya S. ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India

来源：

FEMS MICROBIOLOGY LETTERS | 2012年 / 330卷 / 01期

关键词：

DevR; DosR; DevR binding peptide; phage display; CARBON-MONOXIDE; TRANSCRIPTION; ACTIVATION; OPERON; ASSAYS;

D O I：

10.1111/j.1574-6968.2012.02534.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M.tb). Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained. DevRS1 inhibited DevR-regulated transcription and survival of nonreplicating tubercle bacilli in a hypoxia model of dormancy. DevRS1 peptide-mediated inhibition demonstrates the efficacy of intercepting DevR function to block hypoxic adaptation of M.tb.

引用

页码：66 / 71

页数：6

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