Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?

被引：7
|
作者：
Talaga, P [1 ]
Matagne, A [1 ]
Klitgaard, H [1 ]
机构：
[1] UCB SA, Pharma Sector, B-1420 Braine Lalleud, Belgium
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(01)00200-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new diaryl-methylene piperidine derivative, 2, displayed an atypical antipsychotic profile both in vitro and in vivo. The main pharmacological characteristics of this compound appears to reside in a more potent antagonism of the 5-HT2 serotonergic receptor than of the D2 dopaminergic receptor. This confirms that molecules displaying a D2/5-HT2 binding ratio <1 possess clozapine-like antipsychotic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1313 / 1316
页数：4
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