Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?

被引：7

作者：

Talaga, P ^{[1
]}

Matagne, A ^{[1
]}

Klitgaard, H ^{[1
]}

机构：

[1] UCB SA, Pharma Sector, B-1420 Braine Lalleud, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)00200-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new diaryl-methylene piperidine derivative, 2, displayed an atypical antipsychotic profile both in vitro and in vivo. The main pharmacological characteristics of this compound appears to reside in a more potent antagonism of the 5-HT2 serotonergic receptor than of the D2 dopaminergic receptor. This confirms that molecules displaying a D2/5-HT2 binding ratio <1 possess clozapine-like antipsychotic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1313 / 1316

页数：4

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