Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?

被引：7
|
作者：
Talaga, P [1 ]
Matagne, A [1 ]
Klitgaard, H [1 ]
机构：
[1] UCB SA, Pharma Sector, B-1420 Braine Lalleud, Belgium
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(01)00200-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new diaryl-methylene piperidine derivative, 2, displayed an atypical antipsychotic profile both in vitro and in vivo. The main pharmacological characteristics of this compound appears to reside in a more potent antagonism of the 5-HT2 serotonergic receptor than of the D2 dopaminergic receptor. This confirms that molecules displaying a D2/5-HT2 binding ratio <1 possess clozapine-like antipsychotic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1313 / 1316
页数：4
相关论文
共 50 条
  • [1] Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
    Tomic, M
    Kundakovic, M
    Butorovi, B
    Janac, B
    Andric, D
    Roglic, G
    Ignjatovic, D
    Kostic-Rajacic, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (16) : 4263 - 4266
  • [2] New potential atypical antipsychotic with unusual pharmacological profile
    Laszlovszky, I
    Kiss, B
    Csejtei, M
    Lapis, E
    Kalman, E
    Szabo, S
    Paroczai, M
    Acs, T
    Domany, G
    Karpati, E
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 356 (04) : 124 - 124
  • [3] Aripiprazole: a new atypical antipsychotic with a different pharmacological mechanism
    Naber, D
    Lambert, M
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (08): : 1213 - 1219
  • [4] EARLY ECONOMIC EVALUATION OF THE NEW ATYPICAL ANTIPSYCHOTIC
    Musina, N.
    Vaskova, L.
    Omelyanovskiy, V. V.
    Lemeshko, V
    Teptsova, T.
    VALUE IN HEALTH, 2017, 20 (09) : A714 - A714
  • [5] Homobivalent Ligands of the Atypical Antipsychotic Clozapine: Design, Synthesis, and Pharmacological Evaluation
    McRobb, Fiona M.
    Crosby, Ian T.
    Yuriev, Elizabeth
    Lane, J. Robert
    Capuano, Ben
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (04) : 1622 - 1634
  • [6] EGIS-11148: pharmacological characterization of a new atypical antipsychotic compound
    Levay, G.
    Moriez, K.
    Kompagne, H.
    Kertesz, S.
    Barkoczy, J.
    Harsing, L.
    Gacsalyi, I.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S460 - S460
  • [7] PHARMACOLOGICAL EVALUATION OF SERTINDOLE - A NEW ATYPICAL NEUROLEPTIC
    SKARSFELDT, T
    SCHIZOPHRENIA RESEARCH, 1991, 4 (03) : 326 - 326
  • [8] PHARMACOLOGICAL EVALUATION OF SERTINDOLE - A NEW ATYPICAL NEUROLEPTIC
    SKARSFELDT, T
    PSYCHOPHARMACOLOGY, 1991, 103 (04) : B9 - B9
  • [9] PHARMACOLOGICAL EVALUATION OF A NEW ERGOLIN DERIVATIVE (ERGALGIN)
    BARTSCH, R
    NOWAK, R
    PHARMAZIE, 1979, 34 (5-6): : 358 - 358
  • [10] PHARMACOLOGICAL EVALUATION OF CLOMACRAN, A NEW POTENT PSYCHOTROPIC AGENT
    FOWLER, PJ
    ZIRKLE, CL
    MACKO, E
    KAISER, C
    SARAU, H
    TEDESCHI, DH
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1977, 27-1 (04): : 866 - 872
12345