Recent advance in the structural analysis of HIV-1 envelope protein

被引：1

作者：

Matsuda, Zene ^{[1
,2
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Res Ctr Asian Infect Dis, Tokyo 1088639, Japan

[2] Chinese Acad Sci, Inst Biophys, Lab Struct Virol & Immunol, Beijing 100101, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2015年 / 58卷 / 05期

关键词：

HIV-1; envelope glycoprotein; CryoEM; structure; membrane fusion; vaccine; DEPENDENT EPITOPE; MEMBRANE-FUSION; GLYCOPROTEIN; TRIMERS; GP41; ANTIBODIES; INFECTION; GENE; ENV;

D O I：

10.1007/s11427-015-4852-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus type I (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in resourceful countries. Long-awaited anti-HIV-1 vaccine is still not with us yet; however, great progress in structural analyses of the envelope protein of HIV-1 in recent years starts to shed light on rational intervention targeted at the envelope protein, as will be reviewed in this article.

引用

页码：420 / 424

页数：5

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