Recent advance in the structural analysis of HIV-1 envelope protein

被引：1
|
作者：
Matsuda, Zene [1 ,2 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Res Ctr Asian Infect Dis, Tokyo 1088639, Japan
[2] Chinese Acad Sci, Inst Biophys, Lab Struct Virol & Immunol, Beijing 100101, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2015年 / 58卷 / 05期
关键词：
HIV-1; envelope glycoprotein; CryoEM; structure; membrane fusion; vaccine; DEPENDENT EPITOPE; MEMBRANE-FUSION; GLYCOPROTEIN; TRIMERS; GP41; ANTIBODIES; INFECTION; GENE; ENV;
D O I：
10.1007/s11427-015-4852-1
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human immunodeficiency virus type I (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in resourceful countries. Long-awaited anti-HIV-1 vaccine is still not with us yet; however, great progress in structural analyses of the envelope protein of HIV-1 in recent years starts to shed light on rational intervention targeted at the envelope protein, as will be reviewed in this article.
引用
收藏
页码：420 / 424
页数：5
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