Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

被引：10

作者：

Braganza, Chriselle D. ^{[1
]}

Motozono, Chihiro ^{[2
]}

Sonoda, Koh-Hei ^{[3
]}

Yamasaki, Sho ^{[2
,4
,5
,6
]}

Shibata, Kensuke ^{[3
,4
,7
]}

Timmer, Mattie S. M. ^{[1
]}

Stocker, Bridget L. ^{[1
]}

机构：

[1] Victoria Univ Wellington, Sch Chem & Phys Sci, POB 600, Wellington, New Zealand

[2] Osaka Univ, Res Inst Microbial Dis, Dept Mol Immunol, Osaka, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Ocular Pathol & Imaging Sci, Fukuoka, Japan

[4] Osaka Univ, Immunol Frontier Res Ctr, Lab Mol Immunol, Suita, Osaka 5650871, Japan

[5] Kyushu Univ, Med Inst Bioregulat, Div Mol Immunol, Fukuoka 8128582, Japan

[6] Chiba Univ, Med Mycol Res Ctr, Div Mol Immunol, Chiba 2608673, Japan

[7] Yamaguchi Univ, Grad Sch Med, Syst Biochem Pathol & Regenerat, Ube, Yamaguchi, Japan

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 39期

关键词：

CHAIN;

D O I：

10.1039/d0cc00247j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified.

引用

页码：5291 / 5294

页数：4