Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

被引：10
|
作者：
Braganza, Chriselle D. [1 ]
Motozono, Chihiro [2 ]
Sonoda, Koh-Hei [3 ]
Yamasaki, Sho [2 ,4 ,5 ,6 ]
Shibata, Kensuke [3 ,4 ,7 ]
Timmer, Mattie S. M. [1 ]
Stocker, Bridget L. [1 ]
机构：
[1] Victoria Univ Wellington, Sch Chem & Phys Sci, POB 600, Wellington, New Zealand
[2] Osaka Univ, Res Inst Microbial Dis, Dept Mol Immunol, Osaka, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Ocular Pathol & Imaging Sci, Fukuoka, Japan
[4] Osaka Univ, Immunol Frontier Res Ctr, Lab Mol Immunol, Suita, Osaka 5650871, Japan
[5] Kyushu Univ, Med Inst Bioregulat, Div Mol Immunol, Fukuoka 8128582, Japan
[6] Chiba Univ, Med Mycol Res Ctr, Div Mol Immunol, Chiba 2608673, Japan
[7] Yamaguchi Univ, Grad Sch Med, Syst Biochem Pathol & Regenerat, Ube, Yamaguchi, Japan
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 39期
关键词：
CHAIN;
D O I：
10.1039/d0cc00247j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified.
引用
收藏
页码：5291 / 5294
页数：4
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