Synthesis and antifungal activities of phenylenedithioureas

被引：44
|
作者：
Phuong, T [1 ]
Khac-Minh, T [1 ]
Van Ha, NT [1 ]
Phuong, HTN [1 ]
机构：
[1] HoChiMinh City Med & Pharm Univ, Fac Pharm, Dept Pharmaceut Chem, Ho Chi Minh City, Vietnam
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期
关键词：
dithioure; antifungal; FlexS;
D O I：
10.1016/j.bmcl.2003.11.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and H-1 NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole. (C) 2003 Published by Elsevier Ltd.
引用
收藏
页码：653 / 656
页数：4
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