Febuxostat methanol solvate

被引：11

作者：

Jiang, Qi-Ying ^{[2
]}

Qian, Jing-Jing ^{[3
]}

Gu, Jian-Ming ^{[1
]}

Tang, Gu-Ping ^{[2
]}

Hu, Xiu-Rong ^{[1
]}

机构：

[1] Zhejiang Univ, Ctr Anal & Measurement, Hangzhou 310028, Zhejiang, Peoples R China

[2] Zhejiang Univ, Inst Chem Biol & Pharmaceut Chem, Hangzhou 310028, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷

关键词：

GOUT; HYPERURICEMIA; EFFICACY;

D O I：

10.1107/S1600536811014905

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound {systematic name: [2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (febuxostat) methanol monosolvate}, C16H16N2O3S center dot CH4O, the benzene and thiazole rings in the febuxostat molecule are twisted at 5.3 (1)degrees. In the crystal structure, intermolecular O-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds link the febuxostat and methanol molecules into helical chains along the 2(1) screw axis.

引用

页码：O1232 / U1414

页数：10

共 50 条

[1] Cyclolinopeptide A methanol solvate
Quail, J. Wilson
Shen, J.
Reaney, M. J. T.
Sammynaiken, R.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1913 - U3450
[2] Epoxycytochalasin H methanol solvate
Li, Li-mei
Liu, Yang
Yang, Tai
Yu, Kai-bei
Zou, Qiang
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2010, 66 : O2176 - U2584
[3] Isopentyltriphenylphosphonium bromide methanol solvate
Czerwinski, Edmund W.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O2941 - O2942
[4] COLLETOTRICHIN MONOHYDRATE METHANOL SOLVATE
GOHBARA, M
KOSUGE, Y
SUZUKI, A
TAMURA, S
OHASHI, Y
SASADA, Y
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1977, 33 (APR15): : 1276 - 1278
[5] Gerontoxanthone I methanol solvate
Boonnak, Nawong
Fun, Hoong-Kun
Chantrapromma, Suchada
Karalai, Chatchanok
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O3958 - U2178
[6] Abacavir methanol 2.5-solvate
Pham, Phuong-Truc T.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1937 - U3633
[7] Chasmaconitine 0.5-methanol solvate
Parvez, M
Gul, W
Anwar, S
Miana, GA
Atta-ur-Rahman
Choudhary, MI
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 : 236 - 238
[8] Tetramethylammonium hexanitratolanthanate(III) methanol solvate
Chesman, Anthony S. R.
Turner, David R.
Deacon, Glen B.
Batten, Stuart R.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : M1942 - M1943
[9] PHYSICAL CHARACTERIZATION OF THE METHANOL SOLVATE OF URAPIDIL
BOTHA, SA
CAIRA, MR
GUILLORY, JK
LOTTER, AP
JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (01) : 28 - 34
[10] 2′,2′-Dibenzylideneisophthalohydrazide methanol solvate
Xue, M
Liu, SX
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O759 - O761

← 1 2 3 4 5 →