Design, synthesis and evaluation of carbazole derivatives as PPARa/γ dual agonists and antioxidants

被引：26
|
作者：
Kumar, R
Ramachandran, U
Srinivasan, K
Ramarao, P
Raichur, S
Chakrabarti, R
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol, Sas Nagar 160062, Punjab, India
[2] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Sector 67, Sas Nagar 160062, Punjab, India
[3] Dr Reddys Labs Discovery Res, Hyderabad 500050, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 13期
关键词：
D O I：
10.1016/j.bmc.2005.04.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of hydroxycarbazole derivatives were synthesized and evaluated for PPAR alpha/gamma dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPAR alpha/gamma dual agonists as well. Compounds 10a and 16 were found to be active in animal studies. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4279 / 4290
页数：12
相关论文
共 50 条
  • [41] Photochemical synthesis of carbazole derivatives
    Lab. Chim. Substances Naturelles, URA 485 du CNRS, Université Blaise Pascal, 63177 Aubière Cedex, France
    SYNTH. COMMUN., 4 (657-670):
  • [42] Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists
    Darwish, Khaled M.
    Salama, Ismail
    Mostafa, Samia
    Gomaa, Mohamed S.
    Helal, Mohamed A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 109 : 157 - 172
  • [43] Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists
    Guo, Ting
    Gan, Zongjie
    Chen, Jie
    Wang, Dechuan
    He, Ling
    Song, Qiao
    Xu, Yungen
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (13) : 2964 - 2970
  • [44] Photochemical synthesis of carbazole derivatives
    IbrahimOuali, M
    Missoum, A
    Sinibaldi, ME
    Troin, Y
    Gramain, JC
    SYNTHETIC COMMUNICATIONS, 1996, 26 (04) : 657 - 670
  • [45] MEDI 381-Design, synthesis and biological evaluation of novel PPAR a/g dual agonists
    Kim, Nam-Jung
    Paek, Seung-Mann
    Yun, Hwa-Young
    Koo, Bon Woong
    Nam, Youn-Hee
    Suh, Young-Ger
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [46] Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
    Shan, Bin
    Hou, Hui
    Zhang, Keke
    Li, Rui
    Shen, Chang
    Chen, Zhengyang
    Xu, Peijia
    Cui, Rongrong
    Su, Zhaoming
    Zhang, Changfa
    Yang, Ruirui
    Zhou, Guizhen
    Liu, Yadan
    Guo, Hao
    Chen, Kaixian
    Fu, Wei
    Jiang, Hualiang
    Zhang, Sulin
    Zheng, Mingyue
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (05) : 3327 - 3347
  • [47] Design, synthesis, and evaluation of a series of novel phenylpropanoic acid derivatives agonists for the FFA1
    Yang, Jiaju
    Gu, Enke
    Yan, Ting
    Shen, Daoming
    Feng, Bainian
    Tang, Chunlei
    CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 93 (05) : 900 - 909
  • [48] Synthesis of tetracyclic carbazole derivatives
    Balamurali, R
    Prasad, KJR
    HETEROCYCLIC COMMUNICATIONS, 2001, 7 (02) : 149 - 154
  • [49] SYNTHESIS OF OXETAN CARBAZOLE DERIVATIVES
    GETMANCHUK, YP
    STARENKAYA, VN
    BANDURENKO, LR
    UKRAINSKII KHIMICHESKII ZHURNAL, 1985, 51 (05): : 545 - 548
  • [50] Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors
    Shen, Yanhong
    Li, Baoli
    Xu, Hu
    Zhang, Guoqiang
    PHARMAZIE, 2013, 68 (05): : 307 - 310
12345