Design, synthesis and evaluation of carbazole derivatives as PPARa/γ dual agonists and antioxidants

被引：26

作者：

Kumar, R

Ramachandran, U

Srinivasan, K

Ramarao, P

Raichur, S

Chakrabarti, R

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol, Sas Nagar 160062, Punjab, India

[2] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Sector 67, Sas Nagar 160062, Punjab, India

[3] Dr Reddys Labs Discovery Res, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 13期

关键词：

D O I：

10.1016/j.bmc.2005.04.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of hydroxycarbazole derivatives were synthesized and evaluated for PPAR alpha/gamma dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPAR alpha/gamma dual agonists as well. Compounds 10a and 16 were found to be active in animal studies. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4279 / 4290

页数：12

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