Design, synthesis and evaluation of carbazole derivatives as PPARa/γ dual agonists and antioxidants

被引：26
|
作者：
Kumar, R
Ramachandran, U
Srinivasan, K
Ramarao, P
Raichur, S
Chakrabarti, R
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol, Sas Nagar 160062, Punjab, India
[2] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Sector 67, Sas Nagar 160062, Punjab, India
[3] Dr Reddys Labs Discovery Res, Hyderabad 500050, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 13期
关键词：
D O I：
10.1016/j.bmc.2005.04.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of hydroxycarbazole derivatives were synthesized and evaluated for PPAR alpha/gamma dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPAR alpha/gamma dual agonists as well. Compounds 10a and 16 were found to be active in animal studies. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4279 / 4290
页数：12
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