High Prevalence of High Grade Anal Intraepithelial Neoplasia in HIV-Infected Women Screened for Anal Cancer

被引：19

作者：

Hou, June Y. ^{[1
,2
,3
,4
,5
,6
]}

Smotkin, David ^{[1
,2
,3
,4
,5
,6
]}

Grossberg, Robert ^{[1
,2
,3
,4
]}

Suhrland, Mark ^{[1
,2
,3
,4
]}

Levine, Rebecca ^{[1
,2
,3
,4
]}

Smith, Harriet O. ^{[1
,2
,3
,4
,5
,6
,7
]}

Negassa, Abdissa ^{[5
,6
]}

McAndrew, Thomas C. ^{[5
,6
]}

Einstein, Mark H. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Montefiore Med Ctr, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA

[2] Montefiore Med Ctr, Dept Med, Bronx, NY 10461 USA

[3] Montefiore Med Ctr, Dept Pathol, Bronx, NY 10461 USA

[4] Montefiore Med Ctr, Dept Surg, Bronx, NY 10461 USA

[5] Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10467 USA

[6] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[7] Albert Einstein Canc Ctr, Bronx, NY 10461 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2012年 / 60卷 / 02期

基金：

美国国家卫生研究院;

关键词：

anal cancer screening; anal cytology; high-resolution anoscopy; HPV-associated disease; LESIONS; CYTOLOGY; RISK; PERFORMANCE; POPULATION; ADULTS; MEN;

D O I：

10.1097/QAI.0b013e318251afd9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

引用

页码：169 / 172

页数：4

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