Isotretinoin Oxidation and Electroanalysis in a Pharmaceutical Drug Using a Boron-doped Diamond Electrode

被引：8
|
作者：
Machini, W. B. S. [1 ]
Enache, T. A. [1 ]
Jorge, S. M. A. [1 ,2 ]
Oliveira-Brett, A. M. [1 ]
机构：
[1] Univ Coimbra, Dept Chem, Fac Sci & Technol, P-3004535 Coimbra, Portugal
[2] Univ Estadual Paulista, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
来源：
ELECTROANALYSIS | 2016年 / 28卷 / 11期
关键词：
Isotretinoin; 13-cis-retinoic acid; Electrochemical oxidation; Boron-Doped Diamond; PERFORMANCE LIQUID-CHROMATOGRAPHY; 13-CIS RETINOIC ACID; ALL-TRANS; 13-CIS-RETINOIC ACID; 4-OXO METABOLITES; MASS-SPECTROMETRY; HUMAN SERUM; PLASMA; QUANTIFICATION; SEPARATION;
D O I：
10.1002/elan.201600206
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Isotretinoin redox behaviour, by voltammetry, at the cathodic pre-treated boron doped diamond electrode by cyclic, differential pulse and square wave voltammetry, and by spectrophotometry in a wide pH range, was investigated. The isotretinoin oxidation was an irreversible, diffusion-controlled process, occurred in a three-step cascade mechanism, and the isotretinoin diffusion coefficient D13-cis-RA=7.35x10(-6)cm(2)s(-1), was calculated. The UV-Vis isotretinoin maximum absorption was pH-dependent. The detection limits LOD=0.53M, by differential pulse voltammetry, and LOD=0.38M, by UV-Vis spectroscopy, were obtained. The isotretinoin in the pharmaceutical drug Roacutan((R)), using differential pulse voltammetry, was determined.
引用
收藏
页码：2709 / 2715
页数：7
相关论文
共 50 条
  • [41] Electrochemical oxidation of thiocyanates on a boron-doped diamond electrode in acid media
    Kenova, T. A.
    Vasilieva, I. S.
    Kornienko, V. L.
    Varnin, V. P.
    RUSSIAN JOURNAL OF ELECTROCHEMISTRY, 2013, 49 (11) : 1086 - 1091
  • [42] Electrochemical oxidation of aromatic sulphonated acids on a boron-doped diamond electrode
    Dipartimento di Ingegneria Chimica e di Processo, Università di Genova, P.le J.F. Kennedy 1, Genova 16129, Italy
    Int. J. Environ. Pollut., 2006, 1-3 (64-74):
  • [43] Electrochemical oxidation of aromatic sulphonated acids on a boron-doped diamond electrode
    Panizza, M.
    Cerisola, G.
    INTERNATIONAL JOURNAL OF ENVIRONMENT AND POLLUTION, 2006, 27 (1-3) : 64 - 74
  • [44] Polymerisation occurrence in the anodic oxidation of phosphite on a boron-doped diamond electrode
    Petrucci, Elisabetta
    Montanaro, Daniele
    Merli, Carlo
    ELECTROCHIMICA ACTA, 2008, 53 (15) : 4952 - 4957
  • [45] Direct and mediated electrochemical oxidation of ammonia on boron-doped diamond electrode
    Kapalka, Agnieszka
    Joss, Lisa
    Anglada, Angela
    Comninellis, Christos
    Udert, Kai M.
    ELECTROCHEMISTRY COMMUNICATIONS, 2010, 12 (12) : 1714 - 1717
  • [46] Boron-doped carbon nanotubes modified electrode for electroanalysis of NADH
    Deng, Chunyan
    Chen, Jinhua
    Chen, XiaoLi
    Mao, Chunhui
    Nie, Zhou
    Yao, Shouzhuo
    ELECTROCHEMISTRY COMMUNICATIONS, 2008, 10 (06) : 907 - 909
  • [47] Comparison of the paracetamol electrochemical determination using boron-doped diamond electrode and boron-doped carbon nanowalls
    Niedzialkowski, P.
    Cebula, Z.
    Malinowska, N.
    Bialobrzeska, W.
    Sobaszek, M.
    Ficek, M.
    Bogdanowicz, R.
    Anand, J. Sein
    Ossowski, T.
    BIOSENSORS & BIOELECTRONICS, 2019, 126 : 308 - 314
  • [48] Electrochemical quantification of propoxur using a boron-doped diamond electrode
    Guimaraes Selva, Thiago Matheus
    Longo Cesar Paixao, Thiago Regis
    DIAMOND AND RELATED MATERIALS, 2016, 66 : 113 - 118
  • [49] Electrochemical determination of bisphenol A using a boron-doped diamond electrode
    Pereira, Gabriel F.
    Andrade, Leonardo S.
    Rocha-Filho, Romeu C.
    Bocchi, Nerilso
    Biaggio, Sonia R.
    ELECTROCHIMICA ACTA, 2012, 82 : 3 - 8
  • [50] ELECTROCHEMICAL DETERMINATION OF DICLOFENAC USING BORON-DOPED DIAMOND ELECTRODE
    Ihos, M.
    Remes, A.
    Manea, F.
    JOURNAL OF ENVIRONMENTAL PROTECTION AND ECOLOGY, 2012, 13 (04): : 2096 - 2103
12345