Isotretinoin Oxidation and Electroanalysis in a Pharmaceutical Drug Using a Boron-doped Diamond Electrode

被引：8
|
作者：
Machini, W. B. S. [1 ]
Enache, T. A. [1 ]
Jorge, S. M. A. [1 ,2 ]
Oliveira-Brett, A. M. [1 ]
机构：
[1] Univ Coimbra, Dept Chem, Fac Sci & Technol, P-3004535 Coimbra, Portugal
[2] Univ Estadual Paulista, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
来源：
ELECTROANALYSIS | 2016年 / 28卷 / 11期
关键词：
Isotretinoin; 13-cis-retinoic acid; Electrochemical oxidation; Boron-Doped Diamond; PERFORMANCE LIQUID-CHROMATOGRAPHY; 13-CIS RETINOIC ACID; ALL-TRANS; 13-CIS-RETINOIC ACID; 4-OXO METABOLITES; MASS-SPECTROMETRY; HUMAN SERUM; PLASMA; QUANTIFICATION; SEPARATION;
D O I：
10.1002/elan.201600206
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Isotretinoin redox behaviour, by voltammetry, at the cathodic pre-treated boron doped diamond electrode by cyclic, differential pulse and square wave voltammetry, and by spectrophotometry in a wide pH range, was investigated. The isotretinoin oxidation was an irreversible, diffusion-controlled process, occurred in a three-step cascade mechanism, and the isotretinoin diffusion coefficient D13-cis-RA=7.35x10(-6)cm(2)s(-1), was calculated. The UV-Vis isotretinoin maximum absorption was pH-dependent. The detection limits LOD=0.53M, by differential pulse voltammetry, and LOD=0.38M, by UV-Vis spectroscopy, were obtained. The isotretinoin in the pharmaceutical drug Roacutan((R)), using differential pulse voltammetry, was determined.
引用
收藏
页码：2709 / 2715
页数：7
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