Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography

被引：71
|
作者：
Koenig, K. [1 ,2 ,3 ]
Breunig, H. G. [3 ]
Bueckle, R. [3 ]
Kellner-Hoefer, M. [3 ]
Weinigel, M. [3 ]
Buettner, E. [4 ]
Sterry, W. [5 ]
Lademann, J. [5 ]
机构：
[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92697 USA
[2] Univ Saarland, Dept Biophoton & Laser Technol, D-66123 Saarbrucken, Germany
[3] JenLab GmbH, D-07745 Jena, Germany
[4] APE GmbH, D-13053 Berlin, Germany
[5] Charite, Dept Dermatol, D-10117 Berlin, Germany
来源：
LASER PHYSICS LETTERS | 2011年 / 8卷 / 06期
关键词：
CARS; multiphoton tomography; two-photon; skin; femtosecond laser; cosmetics; lipids; autofluorescence; RAMAN-SCATTERING MICROSCOPY; IN-VIVO; HIGH-SENSITIVITY; STRATUM-CORNEUM; SPECTROSCOPY; TISSUE; MICROSPECTROSCOPY; VITRO;
D O I：
10.1002/lapl.201110014
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
The ultimate challenge for early diagnostics is label-free high-resolution intratissue imaging without taking physical biopsies. A novel hybrid femtosecond laser tomograph provides in vivo optical biopsies of human skin based on non-linear excitation of autofluorescence and the detection of lipids and water by CARS. Applications include skin cancer detection, biosafety tests of intradermal nanoparticles, and the testing of anti-aging products.
引用
收藏
页码：465 / 468
页数：4
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