Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography

被引：71

作者：

Koenig, K. ^{[1
,2
,3
]}

Breunig, H. G. ^{[3
]}

Bueckle, R. ^{[3
]}

Kellner-Hoefer, M. ^{[3
]}

Weinigel, M. ^{[3
]}

Buettner, E. ^{[4
]}

Sterry, W. ^{[5
]}

Lademann, J. ^{[5
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92697 USA

[2] Univ Saarland, Dept Biophoton & Laser Technol, D-66123 Saarbrucken, Germany

[3] JenLab GmbH, D-07745 Jena, Germany

[4] APE GmbH, D-13053 Berlin, Germany

[5] Charite, Dept Dermatol, D-10117 Berlin, Germany

来源：

LASER PHYSICS LETTERS | 2011年 / 8卷 / 06期

关键词：

CARS; multiphoton tomography; two-photon; skin; femtosecond laser; cosmetics; lipids; autofluorescence; RAMAN-SCATTERING MICROSCOPY; IN-VIVO; HIGH-SENSITIVITY; STRATUM-CORNEUM; SPECTROSCOPY; TISSUE; MICROSPECTROSCOPY; VITRO;

D O I：

10.1002/lapl.201110014

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The ultimate challenge for early diagnostics is label-free high-resolution intratissue imaging without taking physical biopsies. A novel hybrid femtosecond laser tomograph provides in vivo optical biopsies of human skin based on non-linear excitation of autofluorescence and the detection of lipids and water by CARS. Applications include skin cancer detection, biosafety tests of intradermal nanoparticles, and the testing of anti-aging products.

引用

页码：465 / 468

页数：4

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