Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields

被引：25
|
作者：
Mustapic, Mislav [1 ,8 ]
Al Hossain, Md Shahriar [1 ]
Horvat, Joseph [1 ]
Wagner, Pawel [2 ]
Mitchell, David R. G. [3 ]
Kim, Jung Ho [1 ]
Alici, Gursel [4 ,5 ]
Nakayama, Yoshitaka [6 ]
Martinac, Boris [6 ,7 ]
机构：
[1] Univ Wollongong, ISEM, Squires Way, North Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Intelligent Polymer Res Inst, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[3] Univ Wollongong, Electron Microscopy Ctr, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[4] Univ Wollongong, Sch Mech Mat & Mechatron Engn, Wollongong, NSW 2522, Australia
[5] Univ Wollongong, ARC Ctr Excellence Electromat Sci, Wollongong, NSW 2522, Australia
[6] Victor Chang Cardiac Res Inst, Mol Cardiol & Biophys Div, Darlinghurst, NSW 2010, Australia
[7] Univ New S Wales, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
[8] Univ Osijek, Dept Phys, Trg Ljudevita Gaja 6, Osijek, Croatia
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2016年 / 226卷
基金：
澳大利亚研究理事会;
关键词：
Drug delivery; Porous Fe3O4; Magnetic fields; Methyl blue; Superparamagnetic; POLYMERIC MICELLES; IN-VITRO; NANOPARTICLES; DOXORUBICIN; MICROSPHERES; PACLITAXEL; LIPOSOMES; BINDING;
D O I：
10.1016/j.micromeso.2015.12.032
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure DC field did not result in any release. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the DC field and oscillate under the influence of the AC field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：243 / 250
页数：8
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