Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields

被引：25
|
作者：
Mustapic, Mislav [1 ,8 ]
Al Hossain, Md Shahriar [1 ]
Horvat, Joseph [1 ]
Wagner, Pawel [2 ]
Mitchell, David R. G. [3 ]
Kim, Jung Ho [1 ]
Alici, Gursel [4 ,5 ]
Nakayama, Yoshitaka [6 ]
Martinac, Boris [6 ,7 ]
机构：
[1] Univ Wollongong, ISEM, Squires Way, North Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Intelligent Polymer Res Inst, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[3] Univ Wollongong, Electron Microscopy Ctr, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[4] Univ Wollongong, Sch Mech Mat & Mechatron Engn, Wollongong, NSW 2522, Australia
[5] Univ Wollongong, ARC Ctr Excellence Electromat Sci, Wollongong, NSW 2522, Australia
[6] Victor Chang Cardiac Res Inst, Mol Cardiol & Biophys Div, Darlinghurst, NSW 2010, Australia
[7] Univ New S Wales, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
[8] Univ Osijek, Dept Phys, Trg Ljudevita Gaja 6, Osijek, Croatia
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2016年 / 226卷
基金：
澳大利亚研究理事会;
关键词：
Drug delivery; Porous Fe3O4; Magnetic fields; Methyl blue; Superparamagnetic; POLYMERIC MICELLES; IN-VITRO; NANOPARTICLES; DOXORUBICIN; MICROSPHERES; PACLITAXEL; LIPOSOMES; BINDING;
D O I：
10.1016/j.micromeso.2015.12.032
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure DC field did not result in any release. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the DC field and oscillate under the influence of the AC field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：243 / 250
页数：8
相关论文
共 50 条
  • [21] ON THE TEMPERATURE-DEPENDENCE OF THE AC SUSCEPTIBILITY OF FE3O4 MAGNETIC FLUIDS
    ABUALJARAYESH, I
    ALRAWI, A
    ABUSAFIA, H
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1993, 119 (1-2) : 87 - 95
  • [22] Synthesis and Properties of Magnetic Fe3O4/PCL Porous Biocomposite Scaffolds with Different Sizes and Quantities of Fe3O4 Particles
    Ge, Jianhua
    Asmatulu, Ramazan
    Zhu, Bo
    Zhang, Qiu
    Yang, Shang-You
    BIOENGINEERING-BASEL, 2022, 9 (07):
  • [23] Magnetic properties improvement in Fe3O4 nanoparticles grown under magnetic fields
    Wang, J
    Zhang, K
    Peng, ZM
    Chen, QW
    JOURNAL OF CRYSTAL GROWTH, 2004, 266 (04) : 500 - 504
  • [24] Controlled assembly of Fe3O4 magnetic nanoparticles on graphene oxide
    Zhang, Yi
    Chen, Biao
    Zhang, Liming
    Huang, Jie
    Chen, Fenghua
    Yang, Zupei
    Yao, Jianlin
    Zhang, Zhijun
    NANOSCALE, 2011, 3 (04) : 1446 - 1450
  • [25] Controlled Synthesis, Characterization and Magnetic Properties of Fe3O4 Nanocrystals
    Fan Shu-Hong
    Guo Xin-Chun
    Liu Yue-Jun
    Liu Hao-Mei
    Yan Ai-Guo
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2009, 25 (02) : 330 - 333
  • [26] Hierarchically nanostructured magnetic hollow spheres of Fe3O4 and γ-Fe2O3:: Preparation and potential application in drug delivery
    Cao, Shao-Wen
    Zhu, Ying-Jie
    Ma, Ming-Yan
    Li, Liang
    Zhang, Ling
    JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (06): : 1851 - 1856
  • [27] Heat-generation behavior of Fe3O4 particles in AC magnetic fields: analysis of microstructures through tilting
    Srivastava, Manas
    Agrawal, Ruchi
    Singh, Atom Rajiv
    Devi, Leishangthem Sanatombi
    Joshi, Rashmi
    Singh, Bheeshma Pratap
    Sarkar, D.
    Singhal, Rakesh Kumar
    Ningthoujam, Raghumani Singh
    DALTON TRANSACTIONS, 2025, 54 (11)
  • [28] Behaviour of iron oxide (Fe3O4) Janus particles in overlapping external AC electric and static magnetic fields
    Ruditskiy, Aleksey
    Ren, Bin
    Kretzschmar, Ilona
    SOFT MATTER, 2013, 9 (38) : 9174 - 9181
  • [29] MAGNETIC-ORDERING IN LAYERED OXIDE STRUCTURES - FE3O4 THIN-FILMS AND FE3O4/NIO SUPERLATTICES
    LIND, DM
    BERRY, SD
    BORCHERS, JA
    ERWIN, RW
    LOCHNER, E
    STOYONOV, P
    SHAW, KA
    DIBARI, RC
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1995, 148 (1-2) : 44 - 45
  • [30] Formation of Dewetted Epitaxial Structures of Fe3O4/Fe and Their Magnetic Switching Properties
    Ye, Jongpil
    Jin, Yongsik
    Lee, Dongchul
    Ju, Seungjin
    Kim, Dong Hwan
    Kim, Dong Seob
    Choi, Jun Woo
    PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS, 2024, 18 (02):
12345