Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields

被引：25
|
作者：
Mustapic, Mislav [1 ,8 ]
Al Hossain, Md Shahriar [1 ]
Horvat, Joseph [1 ]
Wagner, Pawel [2 ]
Mitchell, David R. G. [3 ]
Kim, Jung Ho [1 ]
Alici, Gursel [4 ,5 ]
Nakayama, Yoshitaka [6 ]
Martinac, Boris [6 ,7 ]
机构：
[1] Univ Wollongong, ISEM, Squires Way, North Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Intelligent Polymer Res Inst, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[3] Univ Wollongong, Electron Microscopy Ctr, AIIM Fac Innovat Campus, Squires Way, Wollongong, NSW 2522, Australia
[4] Univ Wollongong, Sch Mech Mat & Mechatron Engn, Wollongong, NSW 2522, Australia
[5] Univ Wollongong, ARC Ctr Excellence Electromat Sci, Wollongong, NSW 2522, Australia
[6] Victor Chang Cardiac Res Inst, Mol Cardiol & Biophys Div, Darlinghurst, NSW 2010, Australia
[7] Univ New S Wales, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
[8] Univ Osijek, Dept Phys, Trg Ljudevita Gaja 6, Osijek, Croatia
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2016年 / 226卷
基金：
澳大利亚研究理事会;
关键词：
Drug delivery; Porous Fe3O4; Magnetic fields; Methyl blue; Superparamagnetic; POLYMERIC MICELLES; IN-VITRO; NANOPARTICLES; DOXORUBICIN; MICROSPHERES; PACLITAXEL; LIPOSOMES; BINDING;
D O I：
10.1016/j.micromeso.2015.12.032
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure DC field did not result in any release. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the DC field and oscillate under the influence of the AC field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：243 / 250
页数：8
相关论文
共 50 条
  • [1] Study of magnetic interactions in a sample of Fe3O4 magnetic nanoparticles in DC and AC fields
    Modestino, M.
    Galluzzi, A.
    Dinelli, F.
    Sarno, M.
    Polichetti, M.
    NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS, 2024, 47 (05):
  • [2] Magnetic domains characterization of crystalline Fe3O4 under DC and AC magnetic field
    Li, Xiang
    Zhu, Xiaojuan
    Pan, Dong
    Xue, Yan
    Jia, Qingqing
    Liu, Fang
    Li, Zhenghua
    MICROSCOPY, 2019, 68 (04) : 310 - 315
  • [3] Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin
    Cheng, Kai
    Peng, Sheng
    Xu, Chenjie
    Sun, Shouheng
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (30) : 10637 - 10644
  • [4] Immobilization of Lipases onto Magnetic Fe3O4 Nanoparticles for Application in Biodiesel Production
    Wang, Xia
    Dou, Peipei
    Zhao, Peng
    Zhao, Chuanming
    Ding, Yi
    Xu, Ping
    CHEMSUSCHEM, 2009, 2 (10) : 947 - 950
  • [5] Influence of fibres diameter on the AC and DC magnetic characteristics of Fe/Fe3O4 fibres based soft magnetic composites
    Neamtu, B., V
    Pszola, M.
    Opris, A.
    Popa, F.
    Marinca, T. F.
    Chicinas, I
    CERAMICS INTERNATIONAL, 2021, 47 (02) : 1865 - 1874
  • [6] Bacterial adsorption onto thin Fe3O4 magnetic nanofilms
    Ansari, F.
    Horvath, R.
    Aref, A.
    Ramsden, J. J.
    NSTI NANOTECH 2008, VOL 2, TECHNICAL PROCEEDINGS: LIFE SCIENCES, MEDICINE, AND BIO MATERIALS, 2008, : 91 - +
  • [7] The Effect of a DC Magnetic Field on the AC Magnetic Properties of Oleic Acid-Coated Fe3O4 Nanoparticles
    Modestino, Michele
    Galluzzi, Armando
    Sarno, Maria
    Polichetti, Massimiliano
    MATERIALS, 2023, 16 (12)
  • [8] Detail Study on ac-dc Magnetic and Dye Absorption Properties of Fe3O4 Hollow Spheres for Biological and Industrial Application
    Sarkar, Debasish
    Mandal, Kalyan
    Mandal, Madhuri
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2014, 14 (03) : 2307 - 2316
  • [9] Magnetoresistance of Fe3O4/Au/Fe3O4 and Fe3O4/Au/Fe spin-valve structures
    van Dijken, S
    Fain, X
    Watts, SM
    Nakajima, K
    Coey, JMD
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2004, 280 (2-3) : 322 - 326
  • [10] Surface Controlled Magnetic Properties of Fe3O4 Nanoparticles
    Mohapatra, Jeotikanta
    Mitra, Arijit
    Bahadur, D.
    Aslam, M.
    SOLID STATE PHYSICS, VOL 57, 2013, 1512 : 318 - 319
12345