Isoxazolone based inhibitors of p38 MAP kinases

被引：36

作者：

Laufer, Stefan A. ^{[1
]}

Margutti, Simona ^{[1
]}

机构：

[1] Univ Tubingen, Dept Pharmaceut & Med Chem, Inst Pharm, D-72076 Tubingen, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 08期

关键词：

D O I：

10.1021/jm701343f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

引用

页码：2580 / 2584

页数：5

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