Isoxazolone based inhibitors of p38 MAP kinases

被引：36
|
作者：
Laufer, Stefan A. [1 ]
Margutti, Simona [1 ]
机构：
[1] Univ Tubingen, Dept Pharmaceut & Med Chem, Inst Pharm, D-72076 Tubingen, Germany
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 08期
关键词：
D O I：
10.1021/jm701343f
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.
引用
收藏
页码：2580 / 2584
页数：5
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