Isoxazolone based inhibitors of p38 MAP kinases

被引：36

作者：

Laufer, Stefan A. ^{[1
]}

Margutti, Simona ^{[1
]}

机构：

[1] Univ Tubingen, Dept Pharmaceut & Med Chem, Inst Pharm, D-72076 Tubingen, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 08期

关键词：

D O I：

10.1021/jm701343f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

引用

页码：2580 / 2584

页数：5

共 50 条

[1] p38 MAP kinases in the heart
Yokota, Tomohiro
Wang, Yibin
[J]. GENE, 2016, 575 (02) : 369 - 376
[2] Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
Kadosh, Dganit Melamed
Beenstock, Jonah
Engelberg, David
Admon, Arie
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
[3] Benzothiazole based inhibitors of p38α MAP kinase
Liu, Chunjian
Lin, James
Pitt, Sidney
Zhang, Rosemary F.
Sack, John S.
Kiefer, Susan E.
Kish, Kevin
Doweyko, Arthur M.
Zhang, Hongjian
Marathe, Punit H.
Trzaskos, James
Mckinnon, Murray
Dodd, John H.
Barrish, Joel C.
Schieven, Gary L.
Leftheris, Katerina
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (06) : 1874 - 1879
[4] Inhibitors of p38α MAP kinase
Chakravarty, S
[J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 37, 2002, 37 : 177 - 186
[5] Efficient adult skeletal muscle regeneration in mice deficient in p38β, p38γ and p38δ MAP kinases
Ruiz-Bonilla, Vanessa
Perdiguero, Eusebio
Gresh, Lionel
Serrano, Antonio L.
Zamora, Monica
Sousa-Victor, Pedro
Jardi, Merce
Wagner, Erwin F.
Munoz-Canoves, Pura
[J]. CELL CYCLE, 2008, 7 (14) : 2208 - 2214
[6] Cell cycle regulation by p38 MAP kinases
Ambrosino, C
Nebreda, AR
[J]. BIOLOGY OF THE CELL, 2001, 93 (1-2) : 47 - 51
[7] p38 MAP kinases: beyond the stress response
Nebreda, AR
Porras, A
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (06) : 257 - 260
[8] The primary structure of p38 gamma: A new member of p38 group of MAP kinases
Li, ZJ
Jiang, Y
Ulevitch, RJ
Han, JH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 228 (02) : 334 - 340
[9] Potent inhibitors of the map kinase p38
Henry, JR
Rupert, KC
Dodd, JH
Turchi, IJ
Wadsworth, SA
Cavender, DE
Schafer, PH
Siekierka, JJ
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (23) : 3335 - 3340
[10] The development p38 MAP kinase inhibitors
Hynes, John
Wu, H.
Dyckman, A. J.
Lin, S.
Wrobleski, S. T.
Gillooly, K. M.
McIntyre, K. W.
Pitt, S.
Shen, D. R.
Shuster, D. J.
Xia, X.
Zhang, R.
[J]. INFLAMMATION RESEARCH, 2007, 56 : S474 - S474

← 1 2 3 4 5 →