Inhibition of the subgenomic hepatitis C virus replicon in Huh-7 cells by 2′-deoxy-2′-fluorocytidine

被引：61
|
作者：
Stuyver, LJ
McBrayer, TR
Whitaker, T
Tharnish, PM
Ramesh, M
Lostia, S
Cartee, L
Shi, JX
Hobbs, A
Schinazi, RF
Watanabe, KA
Otto, MJ
机构：
[1] Pharmasset Inc, Tucker, GA 30084 USA
[2] Emory Univ, Sch Med, Vet Affairs Med Ctr, Dept Pediat, Decatur, GA 30033 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 02期
关键词：
D O I：
10.1128/AAC.48.2.651-654.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target.
引用
收藏
页码：651 / 654
页数：4
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